PPIE (gene)
Peptidyl-prolyl cis-trans isomerase E is an enzyme that in humans is encoded by the PPIE gene.[1][2]
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities and also exhibit RNA-binding activity. Three alternatively spliced transcript variants encoding distinct isoforms have been observed.[2]
Interactions
PPIE (gene) has been shown to interact with MLL.[3]
References
- ^ Kim JO, Nau MM, Allikian KA, Makela TP, Alitalo K, Johnson BE, Kelley MJ (Oct 1998). "Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines". Oncogene 17 (8): 1019–26. doi:10.1038/sj.onc.1202006. PMID 9747881.
- ^ a b "Entrez Gene: PPIE peptidylprolyl isomerase E (cyclophilin E)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10450.
- ^ Fair, K; Anderson M, Bulanova E, Mi H, Tropschug M, Diaz M O (May. 2001). "Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells". Mol. Cell. Biol. (United States) 21 (10): 3589–97. doi:10.1128/MCB.21.10.3589-3597.2001. ISSN 0270-7306. PMC 100280. PMID 11313484. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100280.
Further reading
- Mi H, Kops O, Zimmermann E, et al. (1997). "A nuclear RNA-binding cyclophilin in human T cells". FEBS Lett. 398 (2–3): 201–5. doi:10.1016/S0014-5793(96)01248-3. PMID 8977107.
- Fair K, Anderson M, Bulanova E, et al. (2001). "Protein Interactions of the MLL PHD Fingers Modulate MLL Target Gene Regulation in Human Cells". Mol. Cell. Biol. 21 (10): 3589–97. doi:10.1128/MCB.21.10.3589-3597.2001. PMC 100280. PMID 11313484. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=100280.
- Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370266.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
|
PDB gallery
|
|
|
|
1zmf: C domain of human cyclophilin-33(hcyp33)
|
|
|
2cqb: Solution Structure of the RNA recognition motif in Peptidyl-prolyl cis-trans isomerase E
|
|
|
|